Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. SIRT7 thereby acts as a transcription repressor. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). ![]() SIR2L7 NAD-dependent protein deacetylase sirtuin-7 Regulatory protein SIR2 homolog 7 SIR2-like protein 7 SIRT7 ![]() Aliquot into multiple vials to avoid repeated freeze-thaw cycles. KLH conjugated synthetic peptide derived from human SIRT7Īqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. ![]() SIRT7 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
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